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Teacher: R. Visintin - Dates: 9-12 January 2018

Format
1 lecture and 1 practical activity every day

Tuesday, 9 January, 2018
9.30-10.30

Welcome

R.Visintin - IEO - Milan
Lesson Location: 
Gold Room
10.30-11.30

Literature Analysis: How to Read a Paper

R.Visintin - IEO - Milan
Lesson Location: 
Gold Room
11.30-12.30

Literature Analysis: How to prepare a Journal Club + Exercise

R.Visintin - IEO - Milan
Lesson Location: 
Gold Room
14.00-17.00

Experimental design: critical thinking, protocol writing, data analysis

R.Visintin - IEO - Milan
Lesson Location: 
Gold Room
Wednesday, 10 January, 2018
9.30-12.30

How to talk about science: Oral &Poster presentations

R.Visintin - IEO - Milan
Lesson Location: 
Gold Room
14.00-15.00

Scientific Writing

R.Visintin - IEO - Milan
Lesson Location: 
Gold Room
15.00-16.30

Presentation exercise

R.Visintin - IEO - Milan
Lesson Location: 
Gold Room
Friday, 12 January, 2018
9.30-12.30

Group work practical and exercise

R.Visintin - IEO - Milan
Lesson Location: 
Conference Room

Organizer: F. Ambrogi, University of Milan - Dates: 15-19 January 2018

The course will introduce the basic statistical tool and concepts of descriptive and inferential statistics. The lectures will be based on the book “Data Analysis for the Life Sciences with R”.  The learning approach will also be through the direct use of the software “to relate the concepts to data analysis”. The book used for the course focuses on the use of the computer for doing data analysis rather than on mathematics. However some mathematical aspects will be explained to get better intuition of the algorithms behind the software itself. During the course the free R software will be introduced. Students are required to bring their own laptops with the most recent version of R installed.

 

Monday, 15 January, 2018
9.30-11.00

Introduction to descriptive statistics: distributions and their representation; summary measures of position and dispersion. 

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
11.30-13.00

Plots to avoid.

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
14.00-16.00

Probablity and diagnostic tests.

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
Tuesday, 16 January, 2018
9.30-11.00

Introduction to statistical inference: Random Variables, the Null Hypothesis, Distributions, Sampling and the Central Limit Theorem.

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
11.30-13.00

Testing statistical significance and building confidence intervals.

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
15.00-17.00

Exercises

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
Wednesday, 17 January, 2018
9.30-13.00

Introduction to the R software

G. Marano UNIMI
Lesson Location: 
Gold Room
15.00-17.00

Introduction to the R software

G. Marano UNIMI
Lesson Location: 
Gold Room
Thursday, 18 January, 2018
9.30-11.00

Association tests.

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
11.30-13.00

Matrix Algebra.

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
14.00-16.00

Linear Models: the Design Matrix, standard errors, interactions, collinearity, confounding.

F. Ambrogi UNIMI
Lesson Location: 
Gold Room
Friday, 19 January, 2018
9.30-11.00

Exercises on the linear model. 

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
11.30-13.00

A short introduction to survival analysis

F.Ambrogi UNIMI
Lesson Location: 
Gold Room
14.00-16.00

Exercise on survival analysis

F.Ambrogi UNIMI
Lesson Location: 
Gold Room

Organizer: Ylli Doksani & Marina Mapelli

Dates: 22-26 January 2018

Monday, 22 January, 2018
9.30-13.00

Working with DNA and RNA

- Working with mammalian genomic DNA
  Y. Doksani - IFOM - Milan

- Visualization of DNA recombination intermediates in S. Cerevisiae
  M. Giannattasio - IFOM - Milan

- Cloning strategies
  D. Piccini - IFOM - Milan

Lesson Location: 
Gold Room
14.00-17.00

- Expression of coding and non-coding genes in mammalian genome
  Francesco Nicassio - IIT - Milan

- Challenges in measuring RNA expression
  Matteo Marzi - IIT - Milan

Lesson Location: 
Gold Room
Tuesday, 23 January, 2018
9.30-13.00

Genetic engineering

- Fundamentals of gene targeting
  S.Casola  - IFOM - Milan

- Gene therapy of genetic diseases: from the bench to the bedside
  G. Ferrari - HSR - Milan

Lesson Location: 
Gold Room
14.00-17.00

- CRISPR technology and its applications in drug discovery
  D.Maddalo  - Novartis - Basel

Protein Biochemistry

- Working with antibodies
  S.Polo - IFOM - Milan

Lesson Location: 
Gold Room
Wednesday, 24 January, 2018
9.30-12.30

Protein Biochemistry

- Protein expression
  M. Mapelli  - IEO - Milan

- Measuring protein interactions in vitro 
  M. Mapelli - IEO - Milan

Lesson Location: 
Gold Room
16.00-17.30

Measuring protein interactions in vivo
S.Sigismund - IFOM - Milan

Lesson Location: 
Gold Room
Thursday, 25 January, 2018
15.00-18.00

Protein Biochemistry

- Capturing specific protein–DNA interactions in biological systems by Chromatin Immunoprecipitation
  I.Dellino  - IEO - Milan

- Protein-DNA interactions involved in DNA repair and DNA replication 
  V.Costanzo - IFOM - Milan

Lesson Location: 
Gold Room
Friday, 26 January, 2018
9.30-13.00

Protein Biochemistry

- Principles of enzymology
  L.Pollegioni - University of Insubria - Varese

- Biochemistry of Ubiquitin
  S.Pasqualato - IEO - Milan

Lesson Location: 
Gold Room
14.00-15.30

Genetic engineering

- Targeted (epi)genome editing and cell therapy applications
  A. Lombardo - HSR - Milan

Lesson Location: 
Gold Room
15.30-17.30

- Case studies

Lesson Location: 
Gold Room

Organizer: Nils Gauthier

Dates: 29-31 January 2018

The course will cover all basic microscopy techniques and provide an overview of a broad range of innovative imaging approaches. Each lecture will include an overview of the topic and a presentation of the lecturer’s specific field of interest.

Monday, 29 January, 2018
9.00-13.00

-Introduction to the course
 N.Gauthier -IFOM - Milan

-Basic principles of microscopy
 P.Maiuri - IFOM - Milan

- Overview of the different types of  microscopy and their applications
   N.Gauthier - IFOM - Milan

Lesson Location: 
Gold Room
14.00-16.00

-Nuclear imaging: from repositioning to polarity  acquisition
 P.Maiuri - IFOM - Milan

Lesson Location: 
Gold Room
16.15-17.00

-Introduction to the case studies activity
 N.Gauthier

Lesson Location: 
Gold Room
Tuesday, 30 January, 2018
9.00-13.00

-Sample preparation for fluorescence microscopy
 S.Barozzi -IFOM - Milan

-Membrane trafficking imaging: from in vitro to in vivo studies
 B.Mesmin IPMC - University of Nice - France

Lesson Location: 
Gold Room
14.00-15.15

-Imaging in small animal: from worm to zebrafish to mice, application for cancer
 G.Deflorian - IFOM - Milan

Lesson Location: 
Gold Room
15.30-17.00

Case studies

Lesson Location: 
Gold Room
Wednesday, 31 January, 2018
9.00-13.00

-Basic principles of Flow Cytometry and Fluorescence Activated Cell Sorting
  MG.Totaro - IFOM - Milan

-How to analyse my images: from image J to matlab, velocity
 P.Maiuri - IFOM - Milan

-Practicals on image analysis
 Gauthier&Maiuri - IFOM - Milan

Lesson Location: 
Gold Room
14.00-16.00

Plasma membrane dynamics and mechanobiology during cell shape changes in health and disease
N.Gauthier - IFOM - Milan

Lesson Location: 
Gold Room
16.15-17.00

Concluding remarks and closure
 

Lesson Location: 
Gold Room

Organizer: Myriam Alcalay

Dates: 31/01- 02/02 2018

Wednesday, 31 January, 2018
11.00-13.30

Principles of Effective Writing

M.Alcalay - IEO - Milan
Lesson Location: 
Meeting room 1-2
15.00-16.00

Grammar in Scientific English

M.Alcalay - IEO - Milan
Lesson Location: 
Meeting room 1-2
16.00-18.00

Exercises

M.Alcalay - IEO - Milan
Lesson Location: 
Meeting Room 1+2
Thursday, 1 February, 2018
9.30-11.30

Writing an original manuscript

M.Alcalay - IEO - Milan
Lesson Location: 
Meeting Room 1+2
11.45-12.45

Plagiarism and Copyrights

S.Petersen-Mahrt - IFOM - Milano
Lesson Location: 
Meeting Room 1+2
14.00-16.00

Exercises: re-write your abstract

Lesson Location: 
Meeting Room 1+2
Friday, 2 February, 2018
14.00-16.00

  Abstracts: before/after

M.Alcalay - IEO - Milan
Lesson Location: 
Meeting Room 1+2

Organizers: D.Pasini, A. Bachi, T. Bonaldi - Dates: 14-21 February 2018

Wednesday, 14 February, 2018
9.30-11.00

Introduction to genomics

Pasini Diego
Lesson Location: 
Gold Room
11.00-12.45

Epigenomics and transcriptomics

Lesson Location: 
Gold Room
15.30-17.00

Practicals and Journal Club

Lesson Location: 
Genomic unit and Gold room
Thursday, 15 February, 2018
9.30-10.45

Non-coding Genome

Nicassio Francesco - IIT
Lesson Location: 
Gold Room
11.00-1215

Single Cell Analyses

Testa Giuseppe
Lesson Location: 
Gold Room
14.30-16.30

Practicals and Journal Club

Lesson Location: 
Genomic unit and Gold room
Friday, 16 February, 2018
9.30-11.00

Computational Approaches for NGS data

Giulio Pavesi - UNIMI
Lesson Location: 
Gold Room
Monday, 19 February, 2018
9.30-11.00

Introduction to MS proteomics

Bachi Angela
Lesson Location: 
Gold Room
11.15-12.45

Quantitative Proteomics

Alessandro Cuomo IEO
Lesson Location: 
Gold Room
15.00-17.30

Practical tutorials for 4 groups - Part 1

Lesson Location: 
tbd
Tuesday, 20 February, 2018
9.30-11.00

Targeted proteomics

Bachi Angela
Lesson Location: 
Gold Room
11.15-12.45

Proteomics in epigenetic research

Bonaldi Tiziana
Lesson Location: 
Gold Room
14.00-15.00

Proteomics in clinical research and drug discovery

Roberta Noberini IEO
Lesson Location: 
Ivory Room
15.00-17.30

Practical tutorials for 4 groups - Part 2

Lesson Location: 
tbd
Wednesday, 21 February, 2018
9.30-11.00

Proteomics and Systems biology

Mauro Fasano - University of Insubria
Lesson Location: 
Gold Room
11.15-12.45

Large-scale data analysis for -omics studies

Jurgen Cox - MPI Martinsried
Lesson Location: 
Gold Room

Organizer: Ugo Cavallaro IEO Milan

Dates: 22,23,26 February 2018

Thursday, 22 February, 2018
9.30-11.00

Genetic screens

L.Lanfrancone - IEO - Milan
Lesson Location: 
Conference Room
11.15-12.45

Viral oncogenes

S.Chiocca - IEO - Milan
Lesson Location: 
Conference Room
14.30-16.00

Genomics and big data, from science to medicine and back

G.Tonon - HSR - Milan
Lesson Location: 
Meeting room 1-2
16.15-17.45

Journal Club

A.Gruszka - IEO - Milan
Lesson Location: 
Meeting room 1-2
Friday, 23 February, 2018
9.30-11.00

Alternative splicing in cancer

J.Valcárcel - CRG - Barcelona
Lesson Location: 
Conference Room
11.15-12.45

How the environment affects cancer genomics

L.Mazzarella - IEO - Milan
Lesson Location: 
Conference Room
14.00-15.00

Scientific seminar

J.Valcárcel - CRG - Barcelona
Lesson Location: 
Conference Room
15.30-17.00

Journal club

M. Giordano - IEO
Lesson Location: 
Meeting room 1-2
Monday, 26 February, 2018
9.30-11.00

Cancer stem cell genetics

G.Testa - IEO - Milan
Lesson Location: 
Conference Room
11.15-12.45

Combining computational and experimental biology to study cancer genetics

F.Demichelis - CiBio - Trento
Lesson Location: 
Conference Room
13.00-14.30

Lunch with Francesca Demichelis

14.30-16.00

Cancer genetics in the clinic: implications and applications

B.Bonanni - IEO - Milan
Lesson Location: 
Meeting room 1-2

Teacher: Paolo Bruzzi, Ospedale San Martino, Genova

Dates: 5-6-7-12-13 March 2018

The general objective of the course is to provide participants with the skills and competences that are needed to review/prepare a clinical research project, or to write/review an article reporting the results of a clinical study.

More specifically, its aims include:

  • to provide a glossary of the terms and concepts most commonly used in clinical studies
  • to offer a general perspective on the methods used in biomedical research and an insight into some of its technical aspects
  • to illustrate the weaknesses and critical aspects of these methods, as currently applied
  • to discuss modern developments in the methodology of clinical trials
  • to offer a conceptual framework for modern medical knowledge and to illustrate the true meaning of evidence-based medical decision

 

Monday, 5 March, 2018
10.00-13.00

- Medicine & Statistics

- Traditional Medical Thinking - Medical Determinism and its crisis

- How to evaluate the effects of a treatment

Lesson Location: 
Gold Room
14.30-17.30

- Phases of Clinical Trials – Activity vs Efficacy

- Clinical Trial – The perfect study

- Study Design, Superiority, Equivalence and non-inferiority

Lesson Location: 
Gold Room
Tuesday, 6 March, 2018
9.00-12.30

Main Features of the Randomised Clinical trial

  • Endpoint and Masking
  • Randomization
  • Intention to treat
  • Statistical Plan
Lesson Location: 
Gold Room
14.00-16.00

How to interpret a clinical trial

  • Internal Validity
  • External validity
  • Internal consistency, Plausibility, External Coherence, Relevancegol
Lesson Location: 
Gold Room
16.00-18.00

Randomised Trials, Uncontrolled Trials and Observational  studies

Lesson Location: 
Gold Room
Wednesday, 7 March, 2018
9.00-12.30

- The Statistical Plan of a clinical study (2)

- Multiplicity (Multiple Endpoints/Interim Analyses/Subgroup Analyses)

- The myth of Precision Medicine

Lesson Location: 
Gold Room
14.00-17.00

- Evaluation of Risk and Prediction of Efficacy of a treatment

- Surrogate endpoints and markers

Lesson Location: 
Gold Room
Monday, 12 March, 2018
10.00-13.00

- Bayesian Statistics

- Clinical Studies in rare diseases

Lesson Location: 
Gold Room
14.30-17.30

- Observational Studies – Ecological vs Analytic Studies

- Types and Main features of observational studies

- Real World Evidence

Lesson Location: 
Gold Room
Tuesday, 13 March, 2018
9.00-13.00

- Evidence Based Medicine – General Concepts

- Systematic Reviews/Pooled analyses

- Medical Decision

Lesson Location: 
Gold Room
14.00-17.00

- New Study Designs

  • Umbrella – Basket Trials
  • Adaptive Studies

- A new concept: The estimands

- Case-Studies

Lesson Location: 
Gold Room

Teachers: Florence Didier, Alice Giudice, IEO

Dates: 3-4-9-16 April 2018

The aim is to propose a basic training for students interested in learning cancer patients needs and concerns, in learning the specificity of the role of the psychologist in Oncology.

 

Tuesday, 3 April, 2018
14.30-18.30

- Introduction: Beginnings of Psychoncology, current situation in psychosocial care

- Psychosocial assessment in cancer patients, relevance of the psychosocial assessment of mental disorders

- Psychosocial distress and prevalence of mental disorders in cancer patients, (causes/stresses specific to cancer, nature of concerns, risk factors)

- Questionnaires and screening procedures of psychosocial distress, mental disorders, coping/ personal and social resources, health related quality of life

- Distress management in cancer patients / psychological- psychosocial interventions (NCCN distress Management Practice Guidelines)

Lesson Location: 
Coral Room
Wednesday, 4 April, 2018
14.30-18.30

Communication and interpersonal skills in cancer care with patient and family (cancer as a family affair, communication of diagnosis, prognosis) 

Lesson Location: 
Coral Room
Monday, 9 April, 2018
14.30-18.30

Communication and interpersonal skills in cancer care with patient and family (emotional stress in Oncology; patients, family and health care professionals)

Lesson Location: 
Coral Room
Monday, 16 April, 2018
14.30-18.30

- Loss, grief and bereavement in Psychoncology and Palliative care

- Psychological interventions

Lesson Location: 
Coral Room

Teacher: Alice Bonomi, Cardiologico Monzino

Dates: 10-13-16-23-24 April 2018

This Applied Biostatistics course provides an introduction to important topics in statistical concepts and reasoning. Each topic will be introduced with examples from published clinical research papers. This course also represents an introduction to basic epidemiological concepts covering study designs and sample size computation. easy-to-use software will be used such as SPSS software.

At the end of the course the learner will know the main concepts of statistics and the main SPSS commands useful for the design of a research protocol.

 

Tuesday, 10 April, 2018
14.30-18.30

Bivariate Analysis:

  • Correlaction
  • Linear Regression

T-test, ANOVA, Non parametric test, Chi-square

Lesson Location: 
Coral Room
Friday, 13 April, 2018
14.30-18.30

Logistic Regression and ROC curve

Lesson Location: 
Coral Room
Monday, 16 April, 2018
9.30-13.30

Multivariate Analysis

Lesson Location: 
Coral Room
Monday, 23 April, 2018
14.30-18.30

Questionnaire analysis

Lesson Location: 
Coral Room
Tuesday, 24 April, 2018
14.30-18.30

Sample size and power calculation

Lesson Location: 
Coral Room

Teacher: Dario Monzani, IEO

Dates: 17-19 April, 7-8-10 May 2018

The main aim of the course is to introduce students to the psychological theory and empirical research related to decision-making in health and medicine. The psychology of medical decision-making could be useful to understand patient, physician and caregiver’s behavior, develop effective interventions to optimize decision-making in health and medicine and improve diagnoses and treatment. Specific learning objectives are:

  • To understand the influence of social, organizational and informational factors on decision-making in health and medicine
  • To understand patient and physician vulnerability to cognition-based errors
  • To develop approaches and intervention to support physicians’ effective decision-making, improve patients’ engagement in making decisions and foster shared decision-making

 

Tuesday, 17 April, 2018
9.30-13.30

Normative and descriptive theories of decision-making

Lesson Location: 
Gold Room
Thursday, 19 April, 2018
9.30-13.30

Clinical decision-making, medical errors, and bias

Lesson Location: 
Coral Room
Monday, 7 May, 2018
9.30-13.30

Shared decision-making and medical decision analysis in practice

Lesson Location: 
Ivory Room
Tuesday, 8 May, 2018
14.30-18.30

Patients’ adherence and behavioral change models

Lesson Location: 
Coral Room
Thursday, 10 May, 2018
14.30-18.30

Personality, individual differences, and health

Lesson Location: 
Coral Room