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Human Genetics positions

Research projects available at CEINGE:

Roberto Berni Canani

  • Gut Microbiome as target for innovative preventive and therapeutic strategies for chronic non-communicable disorders
  • Formulated milk administration to children and their hereditary disorders

Stefano Guido

  • Lab-on-chip microfluidic platforms for applications in medical nanotechnologies

Research projects available at TIGEM:

Alberto Auricchio

  • miRNAs in human eye disease and therapeutic approaches (under the co-supervision of Ivan Conte)
  • Therapeutic genome editing in retina and liver
  • Gene-dependent and -independent approaches for gene therapy of inherited retinal diseases due to mutations in large genes (under the co-supervision of Ivana Trapani)

Andrea Ballabio

  • TFEB-mTORC1 signaling in health and disease
  • Study the role of the lysosome in cystogenesis and rare cancers (under the co-supervision of Chiara Di Malta)
  • Nutrient signaling and metabolic diseases (under the co-supervision of Gennaro Napolitano)

Nicola Brunetti Pierri

  • New therapies for inborn errors of liver metabolism

Davide Cacchiarelli

  • Integrative genomics analyses to study cell fate decisions and rare genetic diseases

Antonella De Matteis

  • Molecular mechanisms of budding and egress of SARS-CoV-2
  • Investigating Lysosomal Storage Diseases mechanisms and progression in iPSC-derived human Kidney Organoids (under the co-supervision of Leopoldo Staiano)

Diego di Bernardo

  • Elucidating the cross-talk among Integrated Stress Response, mTOR signalling and the proteasome during starvation by combining mathematical modelling and microfluidics-based experiments
  • Single-cell lineages and machine learning to identify novel biomarker of drug response in Lynch syndrome (under the co-supervision of Gennaro Gambardella)

Brunella Franco

  • The OFD1 transcript:one gene, several disease
  • Elucidating the role of autophagy in renal cystic disease
  • Modulation of miR-181a/b as a new therapeutic approach for mitochondrial complex I deficiency (MC1DN21)
  • Targeting mitochondrial turnover in rare and common neurodegenerative diseases (under the co-supervision of Alessia Indrieri)

Luis JV Galietta

  • Precision medicine approaches to correct the basic defect in cystic fibrosis and primary ciliary dyskinesia

Paolo Grumati

  • Role of ER-phagy and ER dynamics in cancer

Diego Medina

  • Investigation of the role of tmem175 in lysosomal and autophagic pathways

Pasquale Piccolo

  • Liver-directed gene therapy for inborn error of metabolism with liver fibrosis

Carmine Settembre

  • Regulation of ER-phay in connective tissue disorders