Structural and functional characterization of thyroid trafficking factors
Thyroid hormones are essential for human metabolism and their impairment is related to a number of thyroid and systemic diseases, including cancer, which are currently poorly understood at a molecular level.
The successful PhD candidate will unravel the molecular basis of cell trafficking events regulating the thyroid hormone synthesis, using a combination of single particle cryo-EM, biochemistry, biophysics and cell biology. A background in biochemistry/structural biology is highly desirable.
Group and project info: https://humantechnopole.it/it/gruppi-di-ricerca/coscia-group/
"THYROMOL" European project: https://erc.europa.eu/projects-figures/stories/erc-starting-grants-2021
Keywords: thyroid, cryo-EM, thyroid hormones, thyroid cancer, congenital hypothyroidism, autoimmunity, trafficking, organoids