IEO is a comprehensive cancer center that strives to achieve the excellence in the area of cancer prevention, early diagnosis and effective treatment through the development of clinical and scientific research. The Basic-Research activities of IEO are carried out at the Department of Experimental Oncology. Research is mainly focused on molecular and biological mechanisms of transformation. Emphasis is given to generation of tumor models, applications of high-throughput screening-technologies proteomics, (epi)genomics, structural biology and development of dedicated computational tools and approaches. Research is supported by state-of-the-art technological platforms and facilities including: Genomics, Crystallography, Mass Spectrometry, Imaging, Protein Chemistry, Microarrays.