First name
Luca
Last name
Marelli
Year of Study
Research Center
Thesis Title
The co-production of scientific and Translational induced pluripotent stem Reprogramming platforms. Governance innovation in Cell research
Thesis Abstract
This dissertation charts the rise and articulation of induced Pluripotent Stem Cells (iPSCs) as a prominent translational technology, invested with high expectations to finally deliver the as yet mostly unfulfilled promise of stem cell research. In a field catalyzed by the therapeutic promise, iPSCs have been adopted for widespread translational efforts, in the areas of disease modeling, drug discovery and regenerative medicine, and have progressively positioned themselves, through the mobilization of several biomedical platforms, as a key resource of stem cell-based bioeconomies. Specifically, drawing from extensive ethnographic fieldwork, this work targets distinct iPSC innovation pathways across the United States and the European Union, and conducts the analysis of distinct models of iPSC–based innovation implemented by three leading iPSC research organizations that have been spearheading translational iPSC research: the New York Stem Cell Foundation, the Harvard Stem Cell Institute, and the European Bank for induced Pluripotent Stem Cells – respectively, the largest stem cell research organization in the world; the largest private translational stem cell research institution in the United States; and one of the two flagship stem cell consortia launched in recent years at EU level. Through a comparative approach, this dissertation explores the co-productive relationship between scientific and governance innovation, and probes the distinct ways in which some of the leading research institutions in the field design and implement governance arrangements and practices of standardization in order to harness the innovation potential of iPSC-based technologies. Furthermore, it accounts for the socio-political salience of these emerging institutional configurations, and traces the assembly of distinct constituencies claiming jurisdiction in this domain of biomedicine.
Email
luca.marelli@ieo.eu
Additional Info
Research interests: Science and Technology Studies (STS), Phenomenology, Philosophy of Medicine, Epistemology (disease modeling), Pragmatism.
Education
July 2011: MA in Philosophy, 110/110 summa cum laude, University of Milan.
May 2008: BA in Philosphy, 110/110 summa cum laude, University of Milan.
Lab experience
January - April 2012: In Luisa Lanfrancone's lab at Ifom-Ieo-Campus.
May - October 2012: in Giuseppe Testa's lab at Ifom-Ieo-Campus. Project title: Symmetrical involvement of the 7q11.23 genetic interval in Williams-Beuren syndrome (WBS) and autism spectrum disorders (ASD): modeling mental retardation through somatic cell reprogramming.
Publications
L. Marelli, Esperienza e costituzione. Note sul concetto di prassi nella fenomenologia husserliana, in AA.VV., Pragmatismi, Limina Mentis Editore 2012.
L. Marelli, F. Boem (eds.), Elementi per una genetica forense. Per un codice di procedura genetico, Mondadori 2012.
Conference presentations
"Automating Pluripotency: New Vistas in Biomedical Design", STS Italia Conference "A Matter of Design. Making Society Through Science and Technology", Milan, June 12-14 2014.
Other experiences
February - September 2010: Erasmus student at Katholieke Universiteit Leuven (Belgium).
October 2010 - July 2011: Visiting Student at the Husserl Archives, Higher Institut of Philosophy, Katholieke Universiteit Leuven (Belgium).
July 2010: Summer School in "Genetic Phenomenology", Universität zu Köln.
Summer semester 2012: Adjunct Professor of Hermeneutics and Post-Modern Philosophy, Faculty of Philosophy, Saengtham College, Sampran, Thailand.
November 2012: Cost Action Madrid 2012 Autumn School in "Bio-objects and bio-objectification: a methodology in the making".
2013-2014: Visiting Research Fellow in the Program on Science, Technology and Society, John F. Kennedy School of Government, Harvard university
Awards and affiliation
November 2013 - January 2014: Short-Term Scientific Mission, COST Action IS1001 "Bio-objects and their boundaries: governing matters at the intersection of society, politics, and science", Program on Science, Technology and Society, Harvard Kennedy School
Veronesi Foundation Grant, January 2012 - December 2015.
Erasmus Program Grant, February - September 2010.
Education
July 2011: MA in Philosophy, 110/110 summa cum laude, University of Milan.
May 2008: BA in Philosphy, 110/110 summa cum laude, University of Milan.
Lab experience
January - April 2012: In Luisa Lanfrancone's lab at Ifom-Ieo-Campus.
May - October 2012: in Giuseppe Testa's lab at Ifom-Ieo-Campus. Project title: Symmetrical involvement of the 7q11.23 genetic interval in Williams-Beuren syndrome (WBS) and autism spectrum disorders (ASD): modeling mental retardation through somatic cell reprogramming.
Publications
L. Marelli, Esperienza e costituzione. Note sul concetto di prassi nella fenomenologia husserliana, in AA.VV., Pragmatismi, Limina Mentis Editore 2012.
L. Marelli, F. Boem (eds.), Elementi per una genetica forense. Per un codice di procedura genetico, Mondadori 2012.
Conference presentations
"Automating Pluripotency: New Vistas in Biomedical Design", STS Italia Conference "A Matter of Design. Making Society Through Science and Technology", Milan, June 12-14 2014.
Other experiences
February - September 2010: Erasmus student at Katholieke Universiteit Leuven (Belgium).
October 2010 - July 2011: Visiting Student at the Husserl Archives, Higher Institut of Philosophy, Katholieke Universiteit Leuven (Belgium).
July 2010: Summer School in "Genetic Phenomenology", Universität zu Köln.
Summer semester 2012: Adjunct Professor of Hermeneutics and Post-Modern Philosophy, Faculty of Philosophy, Saengtham College, Sampran, Thailand.
November 2012: Cost Action Madrid 2012 Autumn School in "Bio-objects and bio-objectification: a methodology in the making".
2013-2014: Visiting Research Fellow in the Program on Science, Technology and Society, John F. Kennedy School of Government, Harvard university
Awards and affiliation
November 2013 - January 2014: Short-Term Scientific Mission, COST Action IS1001 "Bio-objects and their boundaries: governing matters at the intersection of society, politics, and science", Program on Science, Technology and Society, Harvard Kennedy School
Veronesi Foundation Grant, January 2012 - December 2015.
Erasmus Program Grant, February - September 2010.
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