Courses

Courses The training activities are held both in Milan and Naples. Check out the corresponding schedules:

Teacher: Rosella Visintin - Dates: 14-18 March 2024

Format: In-Person only course. Lectures and practical activities

Location: IEO, Milan

Timetable
9.30-10.00
Lesson Argument

Introduction to the course

Lesson Location
IEO Silver Room
Timetable
10.00-11.00
Lesson Argument

Critical reading of the literature

Lesson Location
IEO Silver Room
Timetable
11.00-12.15
Lesson Argument

How to do a Journal club

Lesson Location
IEO Silver Room
Timetable
14.00-15.00
Lesson Argument

Experimental design - From hypothesis to conclusions

Lesson Location
IEO Silver Room
Timetable
15.00-16.00
Lesson Argument

Case Study

Lesson Location
IEO Silver Room
Timetable
16.00-17.00
Lesson Argument

Gender diversity in scientific experiments - Susanna Chiocca - IEO - Milan

Lesson Location
IEO Silver Room
Timetable
9.30-11.30
Lesson Argument

Research integrity module:

  • Shared values in scientific research;
  • Running and recording experiments (labnotebook);
  • Generating and manipulating data (scientific misconduct - falsification; fabrication and plagiarism);
  • Time management
Lesson Location
IEO Silver Room
Timetable
11.30-12.30
Lesson Argument

Famous cases of alleged scientific misconduct

Lesson Location
IEO Silver Room
Timetable
14.00-15.00
Lesson Argument

Seminar by William Teale, EMBO Editor

Lesson Location
IFOM - Conference Room
Timetable
9.30-11.30
Lesson Argument

Paper discussion

Lesson Location
IEO Silver Room

Organizer: M. Mapelli (IEO) & A. Casanal (HT) - Dates: 18-21 March 2024

Venue: Human Technopole, Milan

Format: in-person only course

The course will focus on how to analize the structures and on structural biology projects. There will be a day dedicated to Cryo-EM with practicals at the microscope.

Timetable
9.30-11.30
Lesson Argument

Crystallization theory and practical

Teachers

Sebastiano Pasqualato (HT) & Luigi Scietti (IEO)

Lesson Location
Human Technopole - Auditorium
Timetable
11.45-12.45
Lesson Argument

Basis of crystallography

Teachers

Marina Mapelli,

Affiliations

IEO

Lesson Location
Human Technopole - Auditorium
Timetable
14.00-15.00
Lesson Argument

Structure based drug design

Teachers

Mario Milani,

Affiliations

UNIMI

Lesson Location
Human Technopole - Auditorium
Timetable
15.00-17.00
Lesson Argument

Pymol tutorial

Teachers

Sebastiano Pasqualato (HT) & Luigi Scietti (IEO)

Lesson Location
Egg Rooms, 4th floor, PITA
Timetable
9.30-10.20
Lesson Argument

Principles of Cryo-EM SPA

Teachers

Francesca Coscia,

Affiliations

Human Technopole

Lesson Location
Human Technopole - Auditorium
Timetable
10.40-11.30
Lesson Argument

Anatomy of the microscopes and sample preparation

Teachers

Paolo Swuec,

Affiliations

Human Technopole

Lesson Location
Human Technopole - Auditorium
Timetable
11.45-12.45
Lesson Argument

Challenges of a SPA project “Structural Biology impact in drug discovery"

Teachers

Chiara Rapisarda,

Affiliations

Sanofi, Paris

Lesson Location
Human Technopole - Auditorium
Timetable
14.00-14.30
Lesson Argument

Working with Cryo-EM microscopes

Teachers

Paolo Swuec,

Affiliations

Human Technopole

Lesson Location
Egg Rooms, 4th floor PITA
Timetable
14.30-15.00
Lesson Argument

Group 1: Visit to microscopes

Group-2 will alternate with Group-1 for the microscopes’ visit and negative staining tutorial

Teachers

Simona Sorrentino & Malan Silva,

Affiliations

Human Technopole

Lesson Location
Egg rooms 4th floor PITA
Timetable
15.00-15.30
Lesson Argument

Group 1: Negative staining tutorial

Group-2 will alternate with Group-1 for the microscopes’ visit and negative staining tutorial

Teachers

Paolo Swuec & Simona Sorrentino,

Affiliations

Human Technopole

Lesson Location
Egg Rooms 4th floor PITA
Timetable
15.30-17.00
Lesson Argument

Model building tutorial: Coot for model building and structure interpretation of cryoEM maps

Teachers

Martin Høgholm Jørgensen,

Affiliations

Aarhus University, Denmark

Lesson Location
Egg Rooms 4th floor PITA
Timetable
9.30-10.20
Lesson Argument

CLEM: correlative light and electron microscopy

Teachers

Malan Silva,

Affiliations

Human Technopole

Lesson Location
Egg Rooms 4th floor PITA
Timetable
10.40-11.30
Lesson Argument

Principles of Cryo-ET: sample prep and theory

Teachers

Philipp Erdmann,

Affiliations

Human Technopole

Lesson Location
Egg Rooms 4th floor PITA
Timetable
11.45-12.45
Lesson Argument

A Cryo-ET story: “TBD”

Teachers

Mirko Cortese,

Affiliations

TIGEM

Lesson Location
Egg Rooms 4th floor PITA
Timetable
14.00-17.00
Lesson Argument

Cryo-ET workshop and tutorial

Teachers

Philipp Erdmann,

Affiliations

Human Technopole

Lesson Location
Egg Rooms 4th floor PITA
Timetable
9.30-10.20
Lesson Argument

Principles of NMR

Teachers

Giovanna Musco,

Affiliations

San Raffaele Hospital

Lesson Location
Human Technopole - Auditorium
Timetable
10.40-11.30
Lesson Argument

Mass Spectrometry for Structural Biology: XL-MS

Teachers

Andrea Graziadei,

Affiliations

IEO & HT

Lesson Location
Human Technopole - Auditorium
Timetable
11.45-12.45
Lesson Argument

Principles of Alpha-fold

Teachers

Andrea Graziadei,

Affiliations

IEO & HT

Lesson Location
Human Technopole - Auditorium
Timetable
14.00-15.30
Lesson Argument

Alpha-fold tutorial

Teachers

Helen Foster,

Affiliations

Human Technopole

Lesson Location
Egg Rooms 4th floor PITA
Timetable
15.30-17.00
Lesson Argument

Students’ presentation of articles

Teachers

Ana Casañal & Marina Mapelli

Lesson Location
Egg Rooms 4th floor PITA

Organizer: Nereo Kalebic (HT) - Dates: 16-18 April 2024

Venue: Human Technopole, Milan

Format: in-person only course

The course aims at providing a basic theoretical insight into the development and evolution of nervous systems, neuronal physiology, cancer neuroscience and brain pathologies. Through 4 different workshops, tutorials and demonstration, the students will become familiar with various in vitro, ex vivo and in vivo model systems employed in neurobiology as well as basic computational neurogenomic methods.

Timetable
9.00-9.30
Lesson Argument

Introduction to the course

Teachers

Nereo Kalebic,

Affiliations

Human Technopole 

Timetable
9.30-10.30
Lesson Argument

Development and function of neocortex

Teachers

Nereo Kalebic,

Affiliations

Human Technopole

Timetable
10.45-11.45
Lesson Argument

Development and function of cranial placodes

Teachers

Oliver Harschnitz,

Affiliations

Human Technopole

Timetable
11.45-12.45
Lesson Argument

Neuronal guidance and connectivity

Teachers

Dario Bonanomi,

Affiliations

San Raffaele Hospital

Timetable
14.00-15.00
Lesson Argument

Genome editing in PSC-derived models

Teachers

Giovanni Fagà,

Affiliations

Human Technopole

Timetable
15.00-17.00
Lesson Argument

Workshop and tutorial: Genome editing

Teachers

GEDI facility

Timetable
9.00-10.00
Lesson Argument

PSC models to study evolutionary neurobiology

Teachers

Elena Taverna,

Affiliations

Human Technopole

Timetable
10.00-11.00
Lesson Argument

From neurodiversity to physiopathology: an introduction

Teachers

Giuseppe Testa,

Affiliations

Human Technopole & IEO

Timetable
11.30-12.30
Lesson Argument

Human PSC models to study neuroimmunology

Teachers

Oliver Harschnitz

Affiliations

Human Technopole

Timetable
13.30-14.30
Lesson Argument

Single cell manipulation techniques

Teachers

Elena Taverna,

Affiliations

Human Technopole

Timetable
14.30-15.30
Lesson Argument

In vivo models of neurological diseases

Teachers

Manuela Ventura,

Affiliations

Human Technopole

Timetable
15.15-16.15
Lesson Argument

- Tour of the microinjection station (E.Taverna, E.Restelli)
- Tour of the Animal research facility (M.Ventura)                             

Either one after another, or split into 2 groups and doing it in parallel and then exchanging.

Timetable
16.15-18.00
Lesson Argument

Group Work JC

Timetable
9.00-10.00
Lesson Argument

Electrophysiological methods in neuroscience

Teachers

Diletta Pozzi,

Affiliations

Human Technopole

Timetable
10.00-11.00
Lesson Argument

Neuroglial biology and genomics

Teachers

Jose Davila Velderrain,

Affiliations

Human Technopole

Timetable
11.30-12.30
Lesson Argument

Workshop and tutorial Neurogenomics part I

Teachers

Cristina Cheroni,

Affiliations

Human Technopole

Timetable
13.30-15.00
Lesson Argument

Workshop and tutorial Neurogenomics part II

Teachers

Cristina Cheroni,

Affiliations

Human Technopole

Timetable
15.30-17.00
Lesson Argument

JC: Cancer neuroscience

Teachers

Nereo Kalebic and Filippo Mirabella,

Affiliations

Human Technopole

Teachers: Valeria Ranzani (INGM), Camilla Ugolini (IIT)

Dates: 20-23 May 2024

Location: INGM

Timetable
10.00-17.30 with lunch break
Lesson Argument

Usable R fundamentals for biologists

 - Developing a scripting attitude: from GUIs to CLIs
 - IDEs, RStudio, packages and good practices
 - Anatomy of a command, standard output/error, batch & interactive mode
 - R data structures, basic operators, objects, classes
 - Reading data into R objects
 - The Tidyverse. When data are “tidy”?
 - Basic tabular manipulation with dplyr
 - Transformations between wide and long
 - Get quick summarizations with pipes and “group_by"

Teachers

Valeria Ranzani,

Affiliations

INGM

Timetable
10.00-17.30 with lunch break
Lesson Argument

The grammar of graphics with ggplot & data visualization

 - The graphical packages of R
 - The generic R graphic devices, plot command, colours
 - Colours in R, R colour brewer and palettes
 - The grammar of graphics
 - The ggplot2 levels and hierarchy
 - Different types of geoms for different types of data (histograms, bar plots, pie charts, density plots, scatter plots, box plots)
 - Piping summarized data into ggplot
 - Special purpose graphics: volcano, heatmap
 - (optional) Other graphical packages

Teachers

Valeria Ranzani,

Affiliations

INGM

Timetable
10.00-17.30 with lunch break
Lesson Argument

Fundamentals of descriptive statistics

 - Different kind of data, how to distinguish them
 - Basic descriptive indices
 - How to evaluate data position, variability and symmetry
 - How to interpret data position, variability and symmetry
 - Correlation and covariance

Teachers

Valeria Ranzani (INGM) & Camilla Ugolini (IIT)

Timetable
10.00-17.30 with lunch break
Lesson Argument

Bases of statistical inferences

 - Research hypotheses and tests
 - Definition of null and alternative hypothesis
 - The p-value
 - One and two-sided tests
 - (optional) Type I and II errors and power of a test
 - Evaluating performances: Sensitivity and Precision
 - Differences between parametric and non-parametric tests
 - Choosing the most fitting test to answer a question
 - Differences between independent and paired tests
 - How to choose a test

Teachers

Valeria Ranzani (INGM) & Camilla Ugolini (IIT)

Organizer: B. Bodega (INGM) - Dates: 18-19-20 September 2024

The course will be held at INGM, c/o Padiglione Invernizzi, Via Francesco Sforza, 35 – Milan

Timetable
9.15-9.30
Lesson Argument

Introduction to the course

Teachers

Sergio Abrignani,

Affiliations

INGM

Timetable
9.30-11.00
Lesson Argument

Innate and adaptive immunity

Teachers

Sergio Abrignani,

Affiliations

INGM

Lesson Location
INGM Conference Room
Timetable
11.30-13.00
Lesson Argument

Immunological Tolerance

Teachers

Jens Geginat,

Affiliations

INGM

Lesson Location
INGM Conference Room
Timetable
14.00-15.30
Lesson Argument

Transposable elements dynamics regulate T-cell exhaustion in tumor microenvinroment

Teachers

Beatrice Bodega,

Affiliations

INGM

Lesson Location
INGM Conference Room
Timetable
9.30-11.00
Lesson Argument

Metabolic regulation of T cell function and fate

Teachers

Teresa Manzo,

Affiliations

University of Turin - Molecular Biotechnology Center "Guido Tarone"

Lesson Location
INGM Conference Room
Timetable
11.30-13.00
Lesson Argument

B cells

Teachers

Stefano Casola,

Affiliations

IFOM

Lesson Location
INGM Conference Room
Timetable
14.00-15.30
Lesson Argument

Monoclonal antibodies and immunotherapies

Teachers

Antonio Lanzavecchia,

Affiliations

INGM

Lesson Location
INGM Conference Room
Timetable
16.00-17.30
Lesson Argument

Imaging Immunity

Teachers

Matteo Iannacone,

Affiliations

San Raffaele Scientific Institute

Lesson Location
INGM Conference Room
Timetable
9.30-11.00
Lesson Argument

CAR-T

Teachers

Andrea Biondi,

Affiliations

University of Milan-Bicocca

Lesson Location
INGM Conference Room
Timetable
11.30-13.00
Lesson Argument

COVID-19: immune response and vaccines

Teachers

Sergio Abrignani,

Affiliations

INGM

Lesson Location
INGM Conference Room
Timetable
14.00-15.30
Lesson Argument

Genome editing in T cells for cancer immunotherapy

Teachers

Chiara Bonini,

Affiliations

San Raffaele Institute

Lesson Location
INGM Conference Room

Organizer: Ugo Cavallaro (IEO)

Dates: 7-9 October 2024

The course aims to provide a link between the molecular pathogenesis of cancer, experimental approaches for genetic analysis, and the clinical relevance and applications of cancer genetics in oncology.

Timetable
11.00-12.30
Lesson Argument

Genetic screens

Teachers

Luisa Lanfrancone,

Affiliations

IEO

Lesson Location
IFOM - Meeting Room 1-2
Timetable
14.30-16.00
Lesson Argument

Genomics and big data, from science to medicine and back

Teachers

Giovanni Tonon,

Affiliations

HSR - Milan

Lesson Location
IFOM - Meeting Room 1-2
Timetable
16.00-17.30
Lesson Argument

Modeling cancer genetics

Teachers

Alberto Ciccia,

Affiliations

 Columbia University

Lesson Location
ONLINE LECTURE
Timetable
9.30-11.00
Lesson Argument

Alternative splicing in cancer

Teachers

Juan Valcarcel,

Affiliations

CRG - Barcelona

Lesson Location
ONLINE LECTURE
Timetable
11.00-12.30
Lesson Argument

Viral oncogenesis

Teachers

Susanna Chiocca,

Affiliations

IEO

Lesson Location
IFOM - Meeting Room 1-2
Timetable
14.30-16.00
Lesson Argument

Aneuploidy and cancer

Teachers

Stefano Santaguida,

Affiliations

IEO

Lesson Location
IFOM - Meeting Room 1-2
Timetable
14.30-16.00
Lesson Argument

Harnessing genetic alterations in cancer therapy

Teachers

Livio Trusolino,

Affiliations

University of Turin

Lesson Location
IFOM - Meeting Room 1-2
Timetable
16.00-17.30
Lesson Argument

Cancer genetics in the clinic: implications and applications

Teachers

Bernardo Bonanni,

Affiliations

IEO

Lesson Location
IFOM - Meeting Room 1-2